特发性肌炎相关肺间质病与特发性肺纤维化的 临床比较

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Clinical Comparison Between Idiopathic Myositis-associated Interstitial Lung DiseaseandIdiopathicPulmonaryFibrosis

ZHANGMing1，2，ZHOUShuhong3，ZHANGKait，CHENYing3，LIANGLiuna3，ZHANGZhaocui3，PANLiang （1.TheFirstClinicalMedical CollegeofGansu Universityof Chinese Medicine，Lanzhou 73oooo，Gansu，China； 2.DepartmentofImmunorheumatology，ZhangyeSecond People'sHospital，Zhangye7340o，Gansu，China； 3.Department of Immunorheumatology，Gansu Provincial Hospital，Lanzhou 73oooo，Gansu， China； 4.DepartmentofGeriatrics，Shaanxi Second ProvincialPeople's Hospital，Xi'an7o，Shaani，China）

Abstract：Obeiarealcestasitsdo pulmonaryfibrosis（F）.MethodsAtotalof43patientsdagnosedwithDDoerehospitaledinourospitalfroOctobe1o October2021wreselecedAccodingtoeresultsfDA5ntbodytestterddintoDA-Dop（13）ndD group（n=30）Iditio，OpatitsiheospitalizdringteseidreseleedsFoup.Tegeneadiio lnicaymptoatoaiorctodftosseielalds ofdiseaseinDA-DopassortertanthatinoDA-DoupdIouplaniemiotrasferaseandGCOsorsrer thanthosinIopighsilooteiaslerantatinopaineaiotrasferasndOoesheraoe in non-MDA5-ILD group（ P < 0 . 0 1 6 ） .The positive rate of ARSantibody innon-MDA5-ILD group washigher than that in MDA5-ILD group（ P < 0.016）.Thepositive rateof muscleenzyme elevation in IPFgroup was higher than that in MDA5-ILD group（ P<0 . 0 1 6 ） .Male patients，age of onset， （20 D L C O % prereduction，Fscoreand Cscore inIPFgroup were higherthanthose in MDA5-ILDgroupandnon-MDA5-ILD group（ P<0 . 0 1 6 . Thelung functionoftosodsrielaouciiouoTCaifciofDos morecommonwithAIPandOP.TheHRCTclassficationofthenon-MDA5-ILDgroupwasmorecommonwithNSIPConclusionTheclinical characeristicsofeompeelyentfrooofourereiecicalacteris and non-MDA5-ILD.Myositis antibody and HRCTplayan important roleinthe diagnosis and treatmentof ILD.

Key Words：Interstitial lung disease； Idiopathic myositis； Idiopathic pulmonary fibrosis；MDA5antibody

多发性肌炎（polymyositis，PM）和皮肌炎（der-matomyositis，DM）是一组以骨骼肌的免疫炎症为主的自身免疫性疾病，为特发性肌炎（Idiopathic in-flammatorymyopathies，IMs）中最常见的两种类型，可累及皮肤、肺脏、关节等全身器官；累及肺脏出现间质性肺疾病（interstitial lung disease，ILD）是导致患者死亡最重要因素。（剩余9020字）