PI3K/Akt信号通路在中医药靶向骨关节炎中的应用研究

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Applicationof PI3K/Akt Signaling Pathway in Traditional Chinese Medicine Targeting Osteoarthritis

ZHANGDeyu1，PANShengqiang1，LINing2

（1.Clinical CollegeofTraditional ChineseMedicine，Gansu UniversityofTraditional Chinese Medicine，

Lanzhou 73000o， Gansu， China；

2.DepartmentofOrtopedicsndTaumatologyintaoHospitalofaditionalCineseedicin，LintaoO，GsuCina） Abstractarilodtoalreatofadearireisetieat ClinicalndexperimealstudieshavefoundthattraditialCinesemedicinecaniterfewitheourrencendprogressiofAby participatinginhAtsialigthecifnslatedatioofecartililsi andfunctionalracteritofhodrocsbctiatigteifaatorysposeioedinktigalingtatede jointuiuevaadeadeohtldegessefoet signalingpatrovidesargetsndeasfradiioalCineseedcintteveeiOutearlativelylatedasd systematidiscusiosereforesedth3K/AtsigalingathathesearchulsftaditoalCneseicieod compoundpresitosotisatyinecetearsreoredutindertprovideeoreticalbasisforliicalprevetiondtrat of OA.

KeyWords：Osteoarthritis；PI3K/Akt signalingpathway；Traditional Chinese medicine

骨关节炎（osteoarthritis，OA）本质上是一种退行性疾病，现代医学认为OA病因主要涉及滑膜组织炎症变化、不平衡的氧化应激和调节软骨合成代谢和分解代谢的基因的异常表达，这些基因可能是由年龄、肥胖、炎症、创伤和遗传因素等多种潜在危险引起或加剧[12]。（剩余14989字）