基于网络药理学探讨黄芩治疗肺癌的有效成分和作用机制

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Abstract：ObjeciveToanalyethepotentialtargetsandmechansmofadixsuteliaeinthetreatmentoflungcancerbasedoetwork pharacologetodshecieomponntsndargegnesofdiutellieerebandPndeungnced wereobtainedyeCardndOaabasndeintersectioeesofttoeretakenTePetwkdagaofttio geneswasobtaiedusingteStringdatabaseandthGOanalysisndKEGGerichmentanalysisoftekeyargetgeneswereperfodusingthe R （2 softwareustelcagsultsotalofouds4opodgetsd4ngceadetd Therewere55odesnd8eodesinproteininteractionetworkGOfucioalrichentaalysisaied93ologicalprod KEGGpathwayeichentaalysisbained37igalingpathwayseainactivecomponentssuchsogoninicaleincacetind β 1 siosteroleredededUGAKa mainlyncludeEosallellgedialisiis radix scutellariae，such as wogonin，baicalein，acacetin and β -sitosterol，mayact onAKT1，IL6，HIF1A，JUN，CCND1，ESR1，PTGS2，VEGFAand othertargetstougAGERAGE，I7poptosisallcellungancer5ndhersigaigpathwandnplaeolefd scutellariae inanti-lung cancer，showing thecharacteristicsof multi-component，multi-targetand multi-pathway.

KeyWords：Network pharmacology；Radix scutellariae；Lung cancer；Active component

肺癌（lungcancer）作为全球范围内发病率和致死率均居于首位的恶性肿瘤类型，其的疾病负担在临床肿瘤学领域备受关注，从全球癌症流行病学分布特征分析，肺癌呈现出显著的疾病负担二元性特征[1。（剩余11085字）