木犀草素拮抗糖尿病肾病分子机制研究进展

1．昆明医科大学药学院暨云南省天然药物药理重点实验室，云南昆明650500；2．昆明医科大学第一附属医院，云南昆明650000

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【中图分类号】R966 【文献标志码】A 【文章编号】1007－8517（2025）11－0076-07

DOI：10.3969/j. issn.1007-8517.2025.11. zgmzmjyyzz202511016

Research Progress of Luteolin in the Treatment of Diabetic Nephropathy

YU Xiaoze1HUANG Rong1WANG Xuewei²SHI Yunke²MA Yiming2 ZHANG Ling1LUO Min1 CAI Hongyan² LI Yan² YANG Weimin1 * 1.School of Pharmacy，Kunming Medical University and Yunnan Provincial Key Laboratory of Natural Drug Pharmacology，Kunming 65050o，China; 2.The First Afiliated Hospital of Kunming Medical University，Kunming 65OoOo，China

Abstract：Diabetic nephropathyisaserious threatto human health，primarilycharacterizedbyabnormal renalhemodynamics， includinghighglomerularfltratioandpefusionstates.Asthconditionprogresses，teaccumulationofadvancedglycationedproductsgraduallydestroysrenalfiltrationfunction，leadingtoincreasedurinaryalbuminandrenalfailure，amongothersevereconsequences.Thepathogenesisofdiabeticnephropathyiscomplexandinvolvesdisordersinglucosemetabolism，vascular/blodflow，secretionof inflammatorycytokines，xidativestress，andmore.Luteolinisfavooidompoundextractedfromthespecialyplants， suchaslampflowerfoundinYunnanIttargetsthemolecularmechanismsofdiabeticnephropathyndexertsitstherapeuticeffects througharious targetpathways.Luteoliplaysacrucialoleinimprovingmicrociclation，protectingthecardiovascularsystemnti -inflammation，andantioxidantactions.Thisarticleaimstoreviewthemolecularmechanismsofdiabeticnephropathyandthere search progress on the molecular mechanisms of luteolin in treating diabetic nephropathy.

Key words：Diabetic Nephropathy；Luteolin；Target Points；Signal Pathway

糖尿病（diabetesmellitus，DM）是一类以高血糖为主要病理特征的代谢疾病。（剩余17910字）