基于药效及正交设计优选金喉颗粒的提取工艺

打开文本图片集

【中图分类号】R284.2 【文献标志码】A 【文章编号】1007－8517（2025）11－0060-05

DOI：10.3969/j.issn.1007-8517.2025.11. zgmzmjyyzz202511013

Optimization of Extraction Process of Jinhou Granules Based on Pharmacolodynamics and Orthogonal Design

Honghui JIANG Tao* ZENG Chen SU RuihuiCHEN LisiCHEN Xiaojian PENG HongyingWANG Chuany Guangzhou Baiyunshan Jingxiutang Pharmaceutical Company Limited，Guangzhou 51O13O，China

Abstract：Objective Tooptimize theoptimalextraction process ofJinhou granules（JHG）．Methods Basedonthescreeningresultsofpharmacodynamicexperiments，anorthogonalexperimentwasdopted，withtecomprehensivesoreofangiferintraseate anddrycreamieldasevaluationindicators，ndthefactorsofwateradition，extractiontime，ndextractionfrequencyaseaation factors，tooptiizeteextractionprocessofJinhougraulesandonductprocessvalidatioResultsTeanti-amatoryctiityf thewaterextractionprocessofJinhougranulesissuperiortothatoflcoholextractionandwaterextractionandalcoholprcipiation processes.Theoptialextractionprocessistoad10timestheamountof waterandrefuxtwice，achtimefor1.5hour.Thevalidation test results showed that the average transfer rate of mangiferin was 72.30% （ RSD=2.0%，n=3， ，and the dry cream yield was （204 19.20% （RSD=3.5%， n=3 ）.Conclusion The optimized extraction processfor Jinhou granules is stable and feasible with good repeatability，which can provide experimental reference for subsequent production process research.

KeyWords：Jinhou Granules；Orthogonal Design；Extraction Process；Anti-inflammatory effct；Mangiferin

金喉颗粒处方源于中医药大学赵思競教授临床经验方，方中由小金牛草和岗梅两味中药材组成，该品种是由的独家品种金喉散经工艺和剂型改革而来。（剩余6769字）