疏肝健脾法治疗腹泻型肠易激综合征作用机制研究进展

【中图分类号】R256.34 【文献标志码】A 【文章编号】1007－8517（2025）11-0072-04

DOI：10.3969/j. issn.1007-8517.2025.11. zgmzmjyyz202511015

ResearchProgressontheTherapeuticMechanismsofLiver-Soothingand Spleen-Strengthening Therapy forDiarrhea-Predominant Irritable Bowel Syndrome

KANG Hongchang1，2WANG Chunyan1，2LI Mingyue1，2JI Jianbin1.2 1.First Teaching Hospital of Tianjin University of Traditional Chinese Medicine，Tianjin 3Oo38O，China; 2.National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion，Tianjin 30o380，China

Abstract：Diarrea-predominant iritablebowel syndrome（IBS-D）isoneof themostcommonfunctionalbowel disordersand hasdrawsignificantiicalatention.LiverdepressionndspleedeficiecyareecoizedasthefundamenalpathogesisofI D，andtheclinicalaplicationofliver-sothingandspleetrengtheningthrapyhasdemonstratedconsiderablepotentialode research indicatesthatthis therapeuticappoach mayexert itsefectsthrough multiple mechanisms，including：regulating brai-gut peptide expresio，ducngvisralhesesitivity，lvatigintestialifamatosposs，gatingsyolocalacto， modulatingguticoiota，epiingitestialmucosalaiers，andiproinggastrotestialotlitdsods.isvt sizescurrentresearchliteratureonthemechanisticbasisof lver-sothingandspleen-strengtheningtherapyforIBS-D，aimingto provide references for both clinical practice and scientific investigation.

KeyWords：Liver-Soothingand Spleen-Strengthening Therapy；Diarhea-Predominant Iritable Bowel Syndrome（IBSD）；Mechanism of Action；Experimental Research；Review

肠易激综合征（irritablebowel syndrome，IBS）作为临床常见的功能性肠病之一，以腹痛、腹泻或便秘为主要临床表现，且尚未发现器质性疾病可以解释上述症状[1]。（剩余8527字）