Yes相关蛋白作为机械传导效应分子在口腔及其他系统非肿瘤性疾病发生发展中的作用

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[中图分类号]Q257[文献标志码]A [doi]10.7518/gjkq.2025094

Yes-associatedproteinasa mechanotransduction effector molecule in theoccurrenceand development of nonneoplasticdiseasesinoral and othersystems

XueLili’，ChenShuai²，YanBing

1.Dept.oftotlogtherstAfadositalenUeisitynin;tate toryofOral Diseases&National CenterforStomatology&NationalClinical ResearchCenterforOral Diseases&Dept. ofHeadandeckOncologyurgeryWestinaHospitaloftomatologyichanUiversityhengdu6a Supported by：Natural ScienceFoundationofFujianProvince（202lJ05288）

Correspondence：YanBing，Email：yanbing_west@163.com

[Abstract]Yes-asociated protein（YAP）isatranscriptionalcoactivatorthatregulates theexpressonoftargetgenes afterbinding withrelatedtranscription factors inthe nucleus through clasical Hippoornon-Hippopathways.Hence，itdirectly participates incell metabolismand maintains the dynamic balance of cellproliferationand apoptosis.Previous research on YAP mostly focused on neoplastic diseases.In recent years，increasing studies have been conducted on YAP as an extracellular mechanoreceptor in nonneoplastic diseases.This work reviews the molecular mechanism of YAP in nonneoplastic diseases （oraland other systemic diseases）to furtherunderstand itsroleand provide new ideas and strategies forfuture clinical treatment ofrelated diseases.

[Key words] Yes-associated protein； Hippo pathway；non-neoplastic diseases；molecular mechanism

Hippo信号通路最初是在果蝇中被发现的，主要参与调控果蝇发育、细胞生长、增殖及凋亡，其核心蛋白分子为Yki-2]。（剩余16213字）