原花青素对口腔疾病调控机制和防治的研究进展

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[中图分类号]R78 [文献标志码] A [doi] 10.7518/gjkq.2025093

Research progressontheregulatory mechanismand preventionand treatmentofproanthocyanidins inoraldiseases

WuXing²，LiuYuping，ZhangYfan'，XiaYucong，LiZhaohel，YiXiaowei，XiaHong'，ingWenen

1.Dept.ofdicinegchUesityolgyingnina;2ooltotology neseMedicineUniversity，Hangzhou31oo59，ChinaSupportedby：Science ResearchProgramoftheEducationDepartmentofHubeiProvince（D2022430l）;OpenProjectof HubeiEngineeringResearchCenterforSpecialFlowerBiologicalBreeding（2023YBo3）;InnovationandEntrepreneurship Program for College Students ofHubei Province （S202311336023，S202511336046）Correspondence：XiaHong，Email：xiahongvip@l63.com

[Abstract]Proanthocyanidins （PCs），aclassof natural compounds with strong antioxidant propertiesanddiversebiologicalactivities，demonstratesignificantpotentialinthepreventionandtreatmentoforaldiseases.Theyeffectivelypro motetheremineralizationofdentalhardtissues，inhibitthedevelopmentofdentalplaquebiofilms，suppresstheproliferationoforalcancercels，andprovidebeneficialefectsinthetreatmentoforalmucosaldiseases.Thisreview highlights thatthe coreadvantage ofPCs in managing oral diseases stems from theirdual-action mechanism：they not only target andinhibit pathogenic biofilms butalsomodulate thehost’soxidativestressand inflammatoryresponses.Notably，PCs interferewithmicrobialadhesionandbiofilmformationviaanon-bactericidalpathwayofferinganovelstrategytopotentially addressmicrobial drug resistance.Although mostcurrentresearch isconfined tothe laboratorystage，thesafetyandmultipotencyofPCsposition themasapromisingnaturaladjuvantfororaldiseasetherapy.ThisreviewsystematicallysummarizestheapplicationsofPCsinprevalent oral diseases and elucidates their biological mechanisms，aimingtoestablishascientific basis for future clinical translation.

[Keywords]procyanidins;oral diseases;immune regulation; prevention and treatment of diseases

原花青素（proanthocyanidins，PC）是植物中含量丰富的多酚类天然化合物，具有强大的抗氧化和清除自由基的能力，存在抗炎、抗癌和免疫调节等多方面的生物活性1-2。（剩余25059字）