牙源性间充质干细胞来源细胞外囊泡的免疫调节作用

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[中图分类号] Q254 [文献标志码] A [doi] 10.7518/gjkq.2025084

Immune regulation mediated by extracelllar vesicles from dental-derived mesenchymal stem cells

WangBoqun，LuHui，MuQing，ZhaoWei

Dept.ofPediatricDentistryHospitaloftomatologyGuanghuahoolofStomatologySunYat-sen UniversityGuangdongProvincialKeyLaboratoryofStomatology，Guangzhou5oo55，ChinaSupported by：NaturalScienceFoundationofGuangdongProvince（2023A1515012554）;Student Innovationand Entrepreneurship Training Program of Sun Yat-sen University （20240491）Correspondence：ZhaoWei，Email：zhaowei3@mail.sysu.edu.cn

[Abstract]Extracellular vesicles （EVs）released by stem cellscarry various bioactive molecules that are essential for mediating intercellularcommunication.Compared withother tissues-derived stemcels，mesenchymal stemcels derived fromdentaltissespossveraluiqueadvantages，includingcesibilityproliferativecapacityandimmunoulatorypotential.EVssecreted bythese mesenchymal stemcelshave been shownto influenceimmunecellfunctionand modulate inflammatoryresponses within local celular and tisue environments.These immunoregulatory properties are particularlyrelevantinthecontextof inflammation-relateddiseasesresulting fromtrauma，infection，andotherpathologicalstimuli，ighlightingthepotentialoftheseEVsintissuerepairandregenerative medicine.Thisreviewfocusesonthe immunomodulatoryrolesofEVs from mesenchymal stemcellsderived from dentaltissuesand theirregulatory functions in oral and systemic inflammatory diseases.

[Key words] extracellular vesicle；dental-derived mesenchymal stem cell； immune regulation

牙源性间充质干细胞（dental-derivedmesen-chymalstemcell，DMSC）是一类从口腔组织中分离出的成体干细胞，其来源广泛、取材便捷、自我更新与分化能力强大，在再生医学领域中有着广阔的应用前景。（剩余16798字）