基于支架的牙髓组织预血管化技术的研究进展

[中图分类号]R781[文献标志码]A [doi] 10.7518/gjkq.2025061

Research progress on scaffold-based prevascularization technique for dental pulp tissue

1.tomatologyAfliatedorongoliadicalUiversityHot5ona;2hol，ongoliaedical，oo59，ina

[Abstract]Inyoung permanent teethwithpulpnecrosis，currentclinical approach forpulprevascularization does noteffectivelyreconstructfunctionalpulp-like tisueand mayleadtorootcanalcalcification.Consequentlyregenerative endodontic treatmenthasgarnered widespreadatentionfromscholars.The primaryaimdentalpulptissueregeneration is torestoreactivityandfunctionalityautologousdentalpulptisse，withrapid formationafunctional vascularnetworktakenasacriticalsuccssfactor.However，rootcanalandmedullarycavitypresentrelativelynarrow，airtight，ischemic，andhypoxicenvironments，whichimpedesgrowthfunctionalvascularnetworkfromrootcanal to medullary cavity.This challenge has been addressd by researchers who proposed prevascularization technique， which involves formationa functionalvascular network withinengineredtissue toensure anadequate blood supplyto construct.This vascular network cananastomose with host vasculature，ultimately facilitating regenerationvascularizeddentalpulptissue.Thisarticlereviewspotentialcel types，growth factors，andscaffoldsourcspertinentto scafold-based prevascularization technology.Three dimension（3D）bioprinting technologyrelated toprevascularizationis discussed，andaoretical foundationforadvancements inregenerativemedicine isprovided.

[Key words]pulp tissueenginering；pulp tisse regeneration；prevascularization technique;scafold；three dimension bioprinting

牙髓组织再生是将组织工程移植物置入根管内，使牙髓功能恢复到原始状态的技术，目的是使年轻恒牙牙根继续正常生理发育。（剩余28648字）