中药刺五加活性成分抗抑郁作用机制研究进展

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关键词：刺五加；抗抑郁；活性成分；作用机制；调节神经递质；抗氧化；抗炎；免疫调节中图分类号：R285.5文献标志码：A文章编号：1003-9783（2025）07-1214-09doi： 10.19378/j.issn.1003-9783.2025.07.020

Abstract：Major depressive disorder（MDD）is a mood disorder characterized by persistent low mood and loss of interest，afecting emotions，cognition，and behavior.Itisclosely associated with traumaticevents，familial and socialenvironments，and physiological-genetic susceptibility.Currnt treatments primarilyrelyonwestern medications， which often exhibit limitations such as low eficacy，poor tolerability，high relapse rates，andaddiction potential. Traditional Chinese medicine（TCM）has demonstrated significant efficacy in treating depression，attributed to its multi-target and multi-pathway synergistic effects.The Chinese medicinal Acanthopanacis Senticosi Radix etRhizoma seu Caulis exhibits therapeutic properties including liver-soothinganddepresion-relieving，spleen-strengthening and （204 qi -replenishing，and kidney-nourishing and mind-calming efects.Itsactive components comprise glycosides， flavonoids，polysaccarides，coumarin derivatives，amino acids，and various trace nutrients，which exert neuroregulatory，antioxidant，anti-inflammatory，and immunomodulatory efects.Byanalyzing literature fromthe past decade，this review comprehensively explores theactiveconstituents of Acanthopanacis Senticosi Radix et Rhizoma and their underlyingantidepressant mechanisms，providing a systematic understanding of its therapeutic potential in MDD treatment and ofering robust theoretical support for clinical practice and scientific research.

Keywords：Acanthopanacis Senticosi Radix et Rhizoma seu Caulis；antidepressant；active components；mechanism of action；neurotransmitter modulation；antioxidant；anti-inflammatory；immunomodulation

近年来，随着生活节奏的加快与生活压力的增加，抑郁症患病率不断上升，已成为全球范围内的公共卫生问题。（剩余15578字）