基于脂肪组织糖代谢稳态失衡探讨妊娠期糖尿病的中医病机科学内涵

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关键词：妊娠期糖尿病；脂肪细胞因子；葡萄糖代谢失调；棕色脂肪；中医病机中图分类号：R714.25文献标志码：A 文章编号：1003-9783（2025）07-1184-10doi： 10.19378/j.issn.1003-9783.2025.07.017

Abstract：Gestational diabetes mellitus （GDM）is a severe metabolic disorder affecting maternal and infant health and has become amajor public health concern.Traditional Chinese Medicine（TCM）atributes the etiology of GDM to insuffcient innate endowment，improper diet，emotional disturbances，and postnatal malnourishment，with its pathogenesis primarilyrotedinyindeficiency with internalheat.Accumulating clinical evidence supports thatobesityis anindependentrisk factor forGDM，and dysregulation of glucose metabolic homeostasis inadipose tisse is closely linked to GDM development.Guided by the holisticphilosophyof TCM，thisstudyfocusesonadipokines一 metabolicallregulatory factors secreted byadiposetisue—andtheroleof brownadipose tissue in modulating glucose metabolism.It systematicall explores thecorrelationbetween adipose dysfunctionand TCM pathogenesis of GDM，as well aspotential novel strategies forTCM-based interventions.Thiswork providesatheoretical foundation for deciphering the scientificconnotation of TCM pathogenesis in GDM from the perspectiveof adipose tissue glucose metabolismhomeostasisimbalance.

Keywords：gestational diabetes melitus；adipokine；glucose metabolism dysregulation；brown adipose; pathogenesis of traditional Chinese medicine

妊娠期糖尿病（GDM）是指在妊娠期首次发生和发现的糖代谢异常性疾病，以妊娠期血糖异常升高为主要临床表现，严重影响患者健康。（剩余22435字）