α7nAChR在缺血性脑卒中中的神经保护作用与机制研究进展

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中图分类号：R338.2 文献标志码：A 文章编号：2097-7174（2025）11-1100-06

DOI：10.3969/j. issn.2097-7174.2025.11.013

Abstract：Ischemicstrokeisaprevalentcerebrovasculardisorderwithlimitedeffectivetherapeuticinterventions.The α7 nicotinicacetylcholinereceptor（7nAChR），animportantsubtypeofthenon-neuronalcholinergic system，exertspivotal regulatory efects inischemic stroke.Currently，there isalackofcomprehensivesynthesisregardingtheneuroprotective rolesandunderlying mechanisms of α7nAChR in ischemic stroke.This systematic review consolidates recent domestic and foreign literature to elucidate the involvement of ∝/ nAChR across multiple pathophysiological processes in ischemic stroke，includingeuroinflammationpyroptosis，utopagy，erroptosis，uroplasticitymodulationandcrebralglucose metabolism.Theresultsofthe literaturereview indicatethatactivationofα7nAChR post-ischemia promotes cholinergic anti-inflammatorypathways，atenuatesneuroinflammation，modulatesautophagicactivitytopreserveblood-brainbair integrity，inibitsfroptoticcelldath，ducesoxidatiesress，andfcilitatesnti-inflammatoryicroglialpation. These findings highlight α7nAChR asapromising moleculartarget fortherapeutic intervention in ischemic stroke.

Key words： Ischemic stroke；α7 nicotinic acetylcholine receptor；Physiopathology

脑卒中是全球最主要的死亡原因之一，具有高发病率、高致残率和高死亡率的特点[]。（剩余12919字）