咖啡生物碱类主要化合物的提取、合成代谢途径及活性研究进展

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doi：10.13304/j.nykjdb.2024.0557

中图分类号：S59 文献标志码：A 文章编号：1008-0864（2025）08-0132-12

ProgressinExtraction，SyntheticMetabolicPathways，and Bioactivity Researchof Coffea Alkaloid Main Compounds

YANG Linghui1，DING Zhiwei1，GONG Li1，LI Xuejun12，DONG Yunpingl，LYU Zhenjiang 1，2* （2 （ColegeofTopicalCrops，YunnaAgriculturalUniversityYuanu’er665O99，hina;2.YuanKeyLaboratoryofofee YunnanAgricultural University，YunnanPu'er665o99，China）

Abstract：Coffeabelongs totheCoffeagenus，Rubiaceaefamily，andisanimportant tropicaleconomiccrop.Coffee is widelypopulardue toitsunique flavorand biological functions.Cafeineand trigonellineare keycomponents，which comprisethemaifavorofoffe.Teyhavevariousbiologicalactivitiessuchasati-inflmmatoryant-cancer，metabolism regulation，neuroprotectionanddiabetes treatment.Theextractionanddeterminationmethodsofcofeaalkaloids，the syntheticmetabolicpathwaysof majorcompounds，and their biological activitieswere reviewed.Futureresearchdirections wereexplored，includingthediversityofcofeaalkaloidcompounds，extractionanddeterminationmethods，biological activitiesandthedevelopmentofcofeaproducts，whichprovidedatheoreticalreferenceforfurtherresearchoncoffa-related applications.

KeyWords：coffea；caffeine；trigonelline；biosynthetic and degradation pathways；biological activities

咖啡是茜草科（Rubiaceae）咖啡属（Coffea）多年生常绿灌木或小乔木，生性畏寒、不耐久旱、性喜温凉[2，是热带亚热带重要的经济作物之一，具有极高的经济价值3]。（剩余27642字）