结合OPG-RANKL-RANK信号系统探讨艾灸治疗老年性骨质疏松症优势

[关键词］老年性骨质疏松症；艾灸疗法；OPG-RANKL-RANK信号系统 [中图分类号］R285.5 [文献标志码］A [文章编号]0256-7415（2025）11-0150-05 DOl：10.13457/j.cnki.jncm.2025.11.028

Exploration on Advantages of Moxibustion in Treating Senile Osteoporosis Through OPG-RANKL-RANK Signaling System

WU Sai，ZHANG Qijuan，LIU Zhengmao，LI Wanying

RehabilitationMedicineDepartment，WuhanOrthopedicHospitalofIntegratedTraditionalChineseandWesternMedicine/ffiaed HospitalofWuhanSportsUniversity，WuhanHubei43OooO，China

Abstract：This paper focuses on the potential advantages of moxibustion in treating senile osteoporosis （SOP）， usingthe OPG-RANKL-RANK signaling system as a theoretical entry point to explore its mechanism inregulating bone metabolism balance.Given the high prevalenceanddisabilityrates associated with SOP，and theconnection between Chinesemedicine's theory of "kidney governs bones"and modern molecular biology mechanisms，this study aims to systematicallyanalyze the feasibilityof moxibustion in improving bone metabolism imbalancethroughtheregulationof the OPG-RANKL-RANK signaling pathway.The article first elucidates thecore regulatory role of the OPG-RANKLRANK signaling system in bone formation and metabolism.It then examines the pathological characteristicsof SOP， analyzing theintrinsic link betweentheimbalanceofthis signaling pathwayand the traditionalpathogenesisof "kidney yinand yang imbalance."By highlighting the functionsof moxibustion in warming the meridians and unblocking the collateralsand regulating theendocrine system，the paperdemonstrates itspotential efectsonthe OPG/RANKLratio， osteoclast activity，and bone density.Additionally，itsummarizes theclinical advantages of moxibustion therapyin termsof safety，analgesicefects，and metabolicregulation.This comprehensiveanalysis providesa theoretical reference for the integration of tradtional Chineseand western medicine in the preventionand treatmentof SOP.The paper also suggests future research directions for standardizing moxibustion operational parameters.

KeyWords： Senile osteoporosis；Moxibustion therapy；OPG-RANKL-RANK signaling system

随着人口老龄化加剧，老年性骨质疏松症（SOP）已成为威胁公共健康的全球性问题。（剩余7046字）