基于网络药理学及分子对接技术分析失笑散治疗消化性溃疡作用机制

打开文本图片集

[关键词］失笑散；消化性溃疡；网络药理学；分子对接

[中图分类号］R285.1 [文献标志码］A [文章编号]0256-7415（2025）11-0032-07

DOl：10.13457/j.cnki.jncm.2025.11.006

Analysis of Mechanism of Shixiao Powder in Treating Peptic Ulcer Based on Network Pharmacology and Molecular Docking Technology

ZHONG Guozhu 1，2 ，QIU Zhenwen1，RAO Qiuhongl

1.DepartmentofPharmacy，TheFirstAfliatedHospitalofGuangzouUniversityofChineseMedicine，GuangzhouGuangdong510405， China；.DepartmentofPharmacy，GuangzhouHospitalofIntegratedTraditionalandWesternMedicineAfliatedtoGuangzhouUnivesity of Chinese Medicine，Guangzhou Guangdong 5108oo，China

Abstract：Objective：To analyze the mechanism of Shixiao Powder in treating peptic ulcer using network pharmacologyand molecular docking technology.Methods：Chemical components and targets of Shixiao Powder were retrieved from TCMSP，HERB，and SwissTargetPrediction databases.Peptic ulcer-related targets were collcted from DrugBank，GeneCards，and OMIM.Common targets were identifiedvia Venn diagram，anda protein-protein interaction （PPI） network was constructed. KEGG pathway and GO functional enrichment analyses were performed via Metascape.Molecular docking validation was conducted with AutoDockTols.Results：（1）A total of 26 chemical components，459 therapeutic targets，1O05 disease targets，and127 potential targets were identified.GO and KEGG enrichment analyses revealed1831entries and182 singaling pathways，involving biologicalproceses such as positive regulation of phosphorus metabolic processs，receptor complexes，and protein kinase activity，as well as MAPK，

PI3K-Akt，and TNF signaling pathways.（2）Molecular docking demonstrated strong binding between core components（quercetin，kaempferol，isophorone，tocopheryl quinoneand pomolic acid）and key targets（TNF，IL6， AKT1，IL1B，PTGS2）.Conclusion：Shixiao Powder exerts potential therapeutic effects onpeptic ulcer by alleviating inflammatory responses through multi-target and multi-pathway mechanisms.

Keywords：Shixiao Powder；Peptic ulcer；Network pharmacology；Molecular docking

消化性溃疡包括胃溃疡和十二指肠溃疡，在临床上以周期性、规律性上腹部疼痛和不适为主。（剩余8476字）