动物胚胎干细胞定向诱导分化为生殖细胞的研究进展

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中图分类号：S813.3 文献标识码：A 文章编码：1005-8567（2025）03-0063-08

Abstract：Embryonic stemcells（ESCs）are embryonic stemcelswith self-renewal andunlimited diferentiation potential，，andtheycan theoreticallydiffrentiateinto germcells.Atpresent，thedifferentiationofESCs into mature sperm and oocytes has been reported in both human and mouse in vitro.In this paper，the endogenous and exogenous factorsandmethodsof inducingESCstodifferentiate into germcells invitroweresystematicallsummarized，and the latest research progress，prospectandapplication prospect of inducing embryonic stemcells to diferentiate into germ cells both domesticallyand internationallywere reviewed，hoping to provide references for researchers engaged in related research.

Keywords：Embryonicstemcells;Germcells;Induced differentiation;Directed differentiation

近年来，不孕不育症在全球范围内的发生率不断攀升，主要与生殖细胞的数量和质量下降相关，这对传统辅助生殖技术构成了前所未有的挑战。（剩余18159字）