3D打印个性化钛网的GBR术及PRF/Bio-Oss复合物修复牙槽骨缺损的应用

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【中图分类号】R782.12 【文献标志码】A

【AbstractlObjective：Toexplore theappicationof3D-printedpersoalized titaniummesh inguidedboneregeneration（GBR）surgeryandtherepairoflveolarbonedefectsusingplatelet-rchfibrin（PRF）/BioOsscomposites.Methods：Atotalof68patientswithalveolarbonedefects whounderwentGBRbone augmentationsurgeryatDepartmentofOraland Maxillfacial Surgery，GansuProvincialHospitalofTraditionalChinese MedicinebetweenMarch2O21andFebruary2O24 wereenroledinthestudyandrandomlyassigned to either the 3D group（ n =34）or the traditional group（ n =34）.The 3D group was treated with 3D-printed personalized titaniummeshandPRF/Bio-Osscomposites，whilethetraditional groupreceivedconventionaltitaniummeshandPRF/Bio-Osscomposites.Theincreases inheight，width，volumeof alveolarboneandtheincidenceofcomplicationsat2，4and6monthspostoperativelywerecomparedbetwenthetwogroups.Results：Theincreassinhightandwidthofalveolarboeat2，4，and6monthspostoprativelynthe3Dgroup werehigher than thoseinthetraditional group，butthediffrences werenot statisticallysignificant（ P>0.05 ）. Theincreasesinalveolarbonevolumeat2and4monthspostoperativelyinthe3Dgroupwerehigherthanthoseinthetraditionalgroup，utthe differenceswere not statisticallysignificant（ P>0.05） .At6monthspostoperatively，the increaseinalveolarbonevolumewassignificantlyhigher than that inthe traditional group（ P<0.05 ）.The proportions of early exposure，late exposure，total exposure，and wound infectioninthe3Dgroupwereallowerthanthoseinthetraditional group，utthediferences werenotstatisticallysigiicant（ P>0.05 ）.Conclusion ∵ The GBR surgery using 3D-printed personalized titanium mesh and PRF/Bio-Oss composites demonstrated favorable outcomes in the repair of alveolar bone defects.At 6 months postoperatively，thisapproach resulted in a significantly greater increase inalveolar bonevolume comparedto the use of conventional titanium mesh in GBR surgery，without compromising safety.These findings support its potential for broader clinical application and promotion.

【Keywordslalveolarbonedefect;guidedboneregeneration;personalizedtitaniummesh;3Dprinting;platelet-richfbrin;ioOe

牙槽骨缺损可由牙周疾病、外伤、牙齿缺失等多种原因导致，其骨量不足区域需骨增量手术修复治疗，是牙种植治疗的常见难点。（剩余15006字）