PD-1/PD-L1通路在2型固有淋巴细胞功能及哮喘病理机制中的作用研究进展

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【中图分类号】R562.25【文献标志码】A

【AbstractTheroleoftype2innatelymphoidcels（ILC2），asubpopulationof immunecels，inrespiratorydiseaseshasaracted muchaentionILCareivoledinspiratoryiflammation，allrgiceactios，ndssuerepairtoughtheproductioofcin suchasinterleukin-5andinterleukin-13.Recentstudieshaveshownthatinrespiratorydiseasessuchasasthma，chronicobstructive pulmonarydisease，ndbronchiectasis，theactivationandabnoalproliferationofILC2arecloselyrelatedtoteosetandprogs sionof thediseases.ILC2playanimportantroleinthepathogenesisofrespiratorydiseases.Inadition，thePD-1/PD-L1pathway playsanimportantroleinregulatingthefunctionofIC2.ByinhbitingthecytokineproductionandproliferationofILC2，D-1/PDL1 mayregulate thecourseofdiseasessuchasasthma.Thereforeanin-depth studyofILC2andtheir nteraction with theD-1/PDL1pathwaynotonlycontributestoabeteruderstandingoftepathogenesisofrespiatorydiseases，utalsoprovidesnetargetsnd strategies for disease treatment.

【KeywordsItype2innatelymphoidcell;respiratorydisease;interleukin；programedcelldeathproteinl/progammeddeathligand 1

哮喘是一种常见的慢性呼吸道疾病，主要表现为气道炎症、气道高反应性及可逆性气道阻塞，严重影响患者的健康和生活质量。（剩余16308字）