1型糖尿病合并自身免疫性甲状腺疾病的易感基因研究进展

【中图分类号】R725.8【文献标志码】A

【AbstractThecoexistenceoftype1diabetes melitus（TDM）andautoimmunethyroiddisease（AITD）consitutesautoimmune polyendocrinopathysydromeI（APS3）.TheprevalenceofAITDinpatientswithTDMissignificantlyhigherthanthatinthegeneral population.Geeticstudieshaveshonthat tepathogenesisofAPS3isassociatedwithavaretyofsusceptibilitygnes，mong wich HLA-DR（humanleukocyteantigen-Drelated），PTPN2（protein tyrosinephosphatase non-receptor-type 22），CTLA4（cytotoxicTlymphocyteassociatedantigen4）andFOXP3（forkheadoxproteinP3）arecoresusceptibilitygenesallinvoledinteeglationof immunesynapsesandtheactivationofTlymphocytes.Inaddtion，generegionssuchasIL2RA（intereukin-2receptor），VDvitamin Dreceptor），TNF（tumornecrosisfactor），GPR10（Gprotein-coupledreceptor103）havealsobeenconfimedtoberelatedtoAPS3， buttheirmechanismsofationstillneedindepthesearh.TesesusceptibilitygnesareassociatedwithteproductionoforeatibodiesiTDandyjointlygulateTDandtyoidutoantibodies，rovidingageneticasisforiskssessmentarlte ventionadindiidualedtrmtofomoiityoftoass.Thsticteaiallvitatologlotion，immune mechanism，and latest research progress on susceptibility genesbetween T1DM and AITD.

【Key words】type1 diabetes mellitus;autoimmune thyroid disease; autoimmune polyendocrinopathysyndrome II;hyperthyroidism;hypothyroidism

1型糖尿病（type1diabetesmellitus，T1DM）是一种由遗传易感个体在环境等因素作用下，发生T细胞介导的自身免疫性攻击，导致胰腺β细胞破坏和胰岛素绝对缺乏的疾病。（剩余14231字）