气道上皮祖细胞在慢性阻塞性肺疾病中的研究进展

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【关键词】慢性阻塞性肺疾病；气道上皮祖细胞；气道上皮损伤【中图分类号R563； 【文献标志码】A

【AbstractChronicobstructivepulmonary disease（COPD）isacommonchronicairwaydisease thatcanbepreventedandtreated， withelativelyighprevalenceandmortalityates.AiraypithelialinjuryisloselyoiatedwithtepatogenesisofCOandits respiratorycomplications.Airwayepithelialprogenitorcelsmainlycomefromairwaysecretorycelsandcanrepairthedamagedairwayepithelium.Manystudieshaveshownthatthereductioninthenumberofirwayepithelialprogenitorcellanddysfunctiooftese cellsmaybeimportantcausesofCOPDandrespiratorycomplications.Thisarticlereviewstheresearchadvances inthfunctionofairwayepithelialprogenitorcelsinCOPDandthemechanismsofthereductionanddysfunctionofthesecells，inordertoprovidenew ideas for the treatment of COPD and related prognosis targets .

【Key Wordslchronic obstructive pulmonary disease ;airway epithelial progenitor cells ;airway epithelial injury

慢性阻塞性肺疾病（chronic obstructive pulmonary disease，COPD）是一类异质性肺部疾病，由呼吸道和（或）肺泡异常引起呼吸困难、咳嗽、咳痰等慢性呼吸道症状，最终造成气流阻塞持续存在且不断反复恶化的状况I。（剩余18133字）