趋化因子及其受体在认知障碍性疾病中的研究进展

【中图分类号】R741 【文献标志码】A

【AbstractCognitiveimpaimentis themainclinicalmanifestationofmanynervoussystemdiseasessuchasstroke，ultipleslerosis， and neurodegeneration，andneuroinflammationisoneofthekeymechanismsfortheonsetofcognitivedisorders.Chemokiesarea class f highlyconseredsmall-moleculescretoryproteins thatbndtothecoespondingchemokinereceptorslocatedoncellmembrane，activatigowsamsigalingathasndplainganmporantoleinellgationolieratio，rentatodu vival.Inthecentralnervoussystem，chemokinsandteirreceptorsareinvoledinimmuneresponseandcanexertacertaingulatory efectnneuroilammatio.Thisticleviestheesearchadvancesinchemoinsandteireptors incognitivedsorders，o der to provide new insights and targets for the early diagnosis and treatment of related diseases.

【Key words】chemokines;chemokine receptors;neuroinflammation;cognitive impairment;cognitive disorders

趋化因子（chemokines）是一类小蛋白，通常由70～80个氨基酸残基组成。（剩余20866字）