地黄梓醇抗糖脂代谢紊乱相关疾病及其机制的研究进展

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【中图分类号】R961

【文献标志码】A【收稿日期】2025-03-15

Research progress on the mechanisms of action of catalpol from Rehmannia glutinosa against glycolipid metabolic disorders and related diseases

SunMengl，ZhongYangl，YangHanjun’，WanDong²，ZhuHuifeng' （1. College of Pharmaceutical Sciences and Chinese Medicine，Southwest University;2.Emergency Department， The First Afliated Hospital of Chongqing Medical University）

【AbstractCatalpol，teparyactivecomponentof Rhmanniaglutosa，exhibitspotentantioxidantandanti-flammatoryts andregulatoryfectsonglucoseandlipidmetabolism.Thisarticlesystematicallyreviewsrecentstudiesontheimpactofcatalpolin addressing glycolipidmetabolicdisordersandrelateddiseasesandtheunderlying mechainsms.Catalpolcancorect glucoseandlipid metabolismimbalances topreventthedevelopmentandprogresionofdiabetescomplicationsincludingmacrovascularandmicrovasculardiseass，throughmodulatingtheadenosine5’-monophosphateactivatedproteinkinasesignalingpathwaytoregulatelipoenesis andfatoxidationandalteringthephosphorylationoforkheadtranscriptionfactor1andglycogensynthasekinase3toinfluenceglyo gensynthesisandbreakdown.Catalpolplaysaprotectiveroleinthecardiocerebrovascularsystemenalfunction，ndetialstruc tureand functionthrough mediating signalingpathwayssuchasphosphatidylinositol3-kinase/protein kinaseBandoxidizedlowdensitylipoprotein/lectin-likeoxidizedlow-densitylipoproteinreceptor-1.Bysuppressingtheuclearfactorkappa-light-chainenhancerofactivatedBcelspatydndoplasmicluress，atalolaallviateifammatorysposs，higat ing inflammation-induced insulin resistance and glycolipid metabolic disorders.

【Key Words]catalpol;glycolipid metabolism;diabetes complication;mechanism of action

糖脂代谢紊乱是代谢功能障碍综合征（metabolicdys-functionsyndrome，MDS）的一个组成部分，是导致高脂血症、肥胖、糖尿病、动脉粥样硬化以及中风等疾病的重要原因[1-4，或者互为因果，促进疾病进展，严重威胁我国居民的身心健康，也是全世界所共同面临的难题5。（剩余36831字）