3种分次立体定向放射治疗技术在颅内寡转移瘤中剂量学研究
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【中图分类号】R739.41【文献标志码】A【收稿日期】2025-01-05
Three fractionated stereotactic radiotherapy techniques in treatment of intracranial oligometastases：a dosimetric study
RanFengwei’，Li Jiwei²，ZhangKangl，Zhao Xiang'，Wang Zhe'，Li Jianjun'，Wang Pengl （1. Departmentof Oncology，The First Affiliated Hospital ofArmy Medical University ; 2.CNNC Accuray Tianjin Medical Technology Co.，Ltd.）
【AbstractObectiveToomparethdosimetricracteristicoftrefractionatedereotacticdioterapytehqust therapy（TOMO），volumetric-modulatedarctherapy（VMAT），andCyberKnife（CK），inthetreatmentofintracranialoligometastases， andtoassessthosstrbuio，teametiecynddreceinoseliedtgansats（OARs）ethdst spectiveanalysiswasperforedfortheclinicaldataof54patients withintracranialoligometastaseswhounderwentfractionatedstere tacticradiotherapyinTeFstAfliatedHospitalofAyMedicalUniversityinO-2023.VarianEclipse16.1PhysicianWorkstationWasusedtoperformtumortargetvolumedelieation，andMANTEIAAccContour3.2softwarewasusedtoperformthedelieation ofOARs，uchsistesialodndicals.ThedeateducturesndageserrsitedtoOd Eclips treatment planningsystemstodesign threediferentradiothrapyreatmentplans.Relatedkeyparameters wereanalyzedusing thedose-oluehistogramtoevalatethdosimetriccharacteristicsofthesetrediotherapytechniques，icudingcofoityindex （CI）of thetarget，dosehomogeneityindex（HI），beam-ontime，theumberofmonitorunits（MU），andtheexposuredoseofOARs.
Results：All three treatmentplans（TOMO，VMAT，and CK）met the requirements for prescribed dose.TOMO had a slightly better CI thanVMATandCK（1.05vs.1.09and1.17，P<0.001）.VMAThad abetterHI than CKand TOMO（1.15vs.1.28 and1.46，P<0.001）. Intermsofexecution efficiency，VMAThadasignificantlyshorter beam-ontimethan TOMOandCK（5minutes，1633MUvs.10 minutes，8 932MU and 39 minutes，5191 MU， P <0.001）.In terms of theexposuredoseofOARs，CKprovidedthebestprotectionforthelens，withamaximumdoseof15cGyfortherightlensand17 cGy for the leftlens，and TOMO had an advantage in dose control for therightcochlea，with a mean dose of 88cGy ，whileVMAThad thebestperformanceinlimitingthedoseforthespinalcord，withamaximumdoseof31cGy（P
【Keywordsstereotacticadiotherapy;tracranialolgometastases;tomotherapy;volumetric-odulatedrcthrapy;CybKife;do simetry
脑转移瘤是癌症的一种常见并发症，也是最常见的脑肿瘤类型，约有 10%～26% 的癌症患者在病情终末期会发生脑转移，严重影响患者预后和生活质量l。（剩余14054字）
