代谢相关脂肪性肝病对高血压患者冠心病发生的影响

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【中图分类号】R575.5；R541.4 【文献标志码】A

Influence of metabolic-associated fatty liver disease on the development of coronaryartery disease in patients with hypertension

Liu Yuhangl，Yi Xin2 ，Long Yi3 （1.DepartmentofHepaticDiseases，TheFirstAfiliated HospitalofChongqing UniversityofChineseMedicine; 2. Department of Cardiovascular Medicine，The Second Afliated Hospital of Chongqing Medical University; 3.DepartmentofCardiovascularMedicine，TheFirstAfliatedHospitalofChongqing UniversityofChineseMedicine） 【Abstract】Objective：Toinvestigate theinfluenceofmetabolic-associatedfatyliverdisease（MAFLD）onthedevelopmentofcoronaryarterydisease（CAD）inpatients withhypertension（HT）.Methods：Atotalof5344patientswithHTandMAFLDwhowrehospitalizednTheSecondAfiliatedHospitalofChongqingMedicalUniversityandUniversity-TownHospitalofChongqing MedicalUniversity from November 2011 to November 2021 were enrolld as HT + MAFLD group，and 5 344 HT patients without MAFLD who were hospitalizedduring thesameperiodoftimewereenroledascontrolgroup.Clinicaldatawereanalyzedforboth groups.Results：There weresignificant differencesbetween the HT + MAFLD groupand the control groupinage（ 62.6±12.4 years vs. 69.1±11.9 years， P< 0.05）and the incidence rate of CAD[1 931（36.1%）vs.1 542（28.9 % ）’ P <0.05].The multivariate logistic regression analysis showed thatMAFLDgeoingtbes，ttriclarjeifractionotallesteoleremporatprictictfor CADinHTpatints，ithaddsatioof33，5，1.49，.157，983，nd078，spctiely.fteradjusentfoelatedo foundingfactorsfieegesiomodelsreestablisd，ndteultssodtatFLDasanidepedentisctorore velopmentof CADinHTpatients.Conclusion：HTpatients with MAFLDtend tohavearelativelyhighprevalencerateof CAD，nd MAFLD isan independent risk factorfor the development of CAD inHT patients.

【Keywordsabocsoatedfattliverdsease;ypetensionoroayateydseas;dabes;tventriarectiaction; risk factors

高血压（hypertension，HT）已成为影响中老年人健康及生活质量的常见慢性疾病之一。（剩余19652字）