肿瘤微环境内巨噬细胞和T细胞的多胺代谢重编程

打开文本图片集

【中图分类号】R730.3 【文献标志码】A

Metabolic reprogramming of polyamines in macrophages and T cells withinthe tumormicroenvironment

Wang Zhixu，Song Yuxiao，Zhang Bicheng （Cancer Center，Renmin Hospital of Wuhan University）

【AbstractInthetumormicroenvironment（TE），themetabolicreprogrammingofmacropagesandTcelsplaysacriticaloleinthe formationofanimmunosuppresivestateandtumorimmuneescape.Polyamiesarekeysignalingmoleculesandprecursorsforiosynthesis，andthemetabolicstateofpolyaminesprofoundlyregulatethefunctionsof tumorcellandimmunecels.Cytokinesandother substances withintheTMEinducetheexpresionofenzymesrelatedtopolyamine metabolism，drivethemetabolicreprogrammingof polyamines，andthusifluencemacrophageparizationandTcelldiferentiation；meanhile，themetaboliceprogammingofpoly amineseads tothecompetitivedepetionofpolyamieresources witintheTE，promotetumorcelstooptimizeteirmetabolicstrat egiesforsurvivaldvantagesandinhbit thefunctionofimmunecels.erefore，nbitorsofolyaminemetabolismmaybeusedas antitumor drugs by regulating metabolic reprogramming.

【KeywordsItumor microenvironment;macrophages;Tcels;polyamine metabolism;metabolicreprogramming;antitumortherapy

肿瘤微环境（tumormicroenvironment，TME）包含细胞外基质和多种非癌细胞，其中免疫细胞在肿瘤免疫微环境（tumorimmunemicroenvironment，TIME）中扮演关键角色。（剩余12831字）