基于多模态核磁共振探讨抑郁症患者的神经血管耦合研究

打开文本图片集

【中图分类号】R749.4 【文献标志码】A

Neurovascular coupling in patients with depression：a study based on multimodal magnetic resonance imaging

Zhao Yue'，Guo Yuanyuan'，Li Chenglong²，ZhangJuanjuan'，Tian Yanghua' （1.Department ofNeurology，TheFirstAffiliated HospitalofAnhui Medical University; 2.Department of Neurology，The Third Affiliated Hospital of Anhui Medical University）

【Abstract】Objective：Toinvestigatealteredneurovascularcoupling inpatients withdepresion（DEP）usingresting-statefuctional magneticresonanceimaging（MRI）andarterialspin labeling perfusion MRI，aswellasitsasociation withdepressivesptoms. MethodsNeuropsychologicalassessmentandmultimodalMRIscanswereperformedfor25DEPpatientsand35healthycontrols （HCs）.ArterialspinlabelingperfusionMRIwasusedtocalculatecerebralbloodfow（CBF），andfunctionalMRIwasusedtocalculate regionalhomogenity（ReHo）.ThePearsoncorelationcoeffcientbetween CBFandReHoascalulatedtoobtainneurovascularcoupling.Results：Atthewhole-brainlevel，CBF-ReHocoupling wasreducedinDEPpatientscomparedwithHs.Atthebraingion level，CBF-ReHocouplingwasreducedin26brainregionsinDEPpatients，hichweremainlylocatedinthvisualnetwork，the defaultnetworkandtheauditorynetwork.Thecorelationanalysisshowedthatthecouplingvaluesofteleftsubocipitalgyrus，the leftangulargyrus，ndtelefttalauswerenegativelyoelatedwithHamiltonDpresionScalesore.Conclusionreisig nificant reduction in neurovascularcoupling in DEP patients，which is correlated with the severity of DEP.

'Key wordsIdepression;magnetic resonance imaging;cerebral blood flow;regional homogeneity;neurovascular coupling

抑郁症（depression，DEP）是一种常见且严重的精神障碍，其主要临床表现包括持续的情绪低落、兴趣丧失以及认知功能的下降等，严重时会出现自杀观念和行为。（剩余13986字）