胞磷胆碱钠联合经颅刺激治疗脑卒中后认知功能障碍的效果及对认知能力和炎症因子的影响
打开文本图片集
I RehabilitationDepartmentofJingbian CountyPeople'sHospital，Yulin7185oo，China; 2 GastroenterologyDepartment
ofJingbianCounty People'sHospital inYulinCity，Yulin7185oo，China
Corrsepondingauthor：WangHaiyang，Email：15529811701@163.com
【Abstract】Objective To observe and explorethe clinical effects of combined use of repetitive transcranial magnetic stimulation （rTMS）and citicolinesodium therapyoncognitive impairment patients after stroke，as wellas their effects oncognitive abilityand inflammatory factors.MethodsA totalof12Opatients with cognitive impairment after stroke were admitted from May2O22 to November 2O23.They were randomlydivided intoa control group （ n =60，treated with rTMS）and an observation group（ n =60，treated with rTMSand added with citicoline sodium）usingarandomnumber tablemethod.Comparecognitivecognitiveability，abilitytolive，cerebral hemodynamics，and inflammatory factorsbeforeand after treatment were compared.ResultsAfter 4 weeks of treatment，theMontreal Cognitive Assessment Scale （MoCA） score，Activitiesof Daily Living （ADL）score，mean cerebral artery blood flow velocity（Vm），peak cerebral artery flow velocity （Vs），and transforming growth factor- （TGF - β1 ） in the observation group were significantly higher than those in the control group，while monocyte chemoatractant protein-1（MCP-1）and interleukin-6 （IL-6） were significantly lower than those in the control group （all P <0.05）.ConclusionrTMS treatment combined with citicoline sodium has a definite therapeutic effect on cognitive impairment patients after stroke，whichcan significantlyreduce neurological deficits，improvecognitive andliving abilities，improvecerebral hemodynamics，and inhibit upregulationof inflammatory factors.
【Key words】 Stroke;Cognitive impairment；Repetitive transcranial magnetic stimulation； Cytidine sodium;Inflammatory factorsDOI：10.19522/j.cnki.1671-5098.2025.01.018
脑卒中发病率、致残率及死亡率高，在中老年人群中多见，尤其是缺血性卒中，脑卒中遗留认知功能障碍的风险高达 30% 及以上1，常导致患者语言功能受损、无法集中注意力、记忆功能减退、执行力下降、思维反应迟缓，严重影响患者认知能力及日常生活质量[2]。（剩余5485字）