肌酸激酶总胆红素与 ∝ -羟丁酸脱氢酶在新生儿溶血病筛查中检测意义与价值分析

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Analysisofthe significanceand value ofcreatine kinase，total bilirubinand α -hydroxybutyrate dehydrogenase detectionin the screeningof hemolytic disease of newborns

Liang Dan BloodTransfusionepartment，XinyangPeople'sHospital，inyang464oo，ina

【Abstract】ObjectiveTo investigate the significance and value of creatine kinase （CK），total bilirubin （TBIL）and α -hydroxybutyratedehydrogenase （ α -HBD） in neonatal hemolytic disease （HDN） screening.Methods A total of 80 HDN neonates from January 2021 to December 2O23 were selected as the study group，and 80 nonHDN neonates were selected as the control group.The TBIL，direct bilirubin （DBIL），indirect bilirubin （IBIL）and myocardial enzyme profiles ofaspartate amino converting enzyme （AST）， CK， phosphocreatine kinase isoenzyme （CK -MB）， lactate dehydrogenase （LDH）， α -hydroxybutyrate dehydrogenase （ α -HBD）were detected in each group. The correlation between each index and HDN was analyzed.ResultsIn the control group，TBIL[（92.2±2.2）umol/L and （209.9±12.3）μmol/L，t=-84.599， P <0.001]，DBIL[（11.2±2.9）μmol/L and （15.2±3.3）μmol/L， t= -8.068， P <0.001] and IBIL[（80.5±13.0）μmol/L and （180.3±23.2）μmol/L， t= -33.589， P <0.001] were lower than those of the study group， and the diferences were statistically significant. Control group AST[（30.3±7.3）U/L and （45.3±9.2）U/L， t=-11.448 ， P <0.001]，CK-MB[（35.1±8.5）U/Land （48.3±4.6）U/L，t=-12.257，P<0.001]，LDH[（265.0±24.2）U/Land （405.6 ± 19.9）

U/L， t=-40.199， P<0.001. ！ CK[（73.6±12.1）U/L and （384.6±29.5）U/L， t=-87.307 ， P <0.001] and α -HBD [220.64± 48.19 U/L and 384.56±35.57 U/L， t=⋅ -24.478， P<0.001 lin the control group were lower than those of the study group，and the difference was statistically significant. AST，LDH and TBIL were not correlated （ P> 0.05）. CK-b MB（ r =-0.851 ，P<0.001）and CK（ r=-0.792 ， P<0.001 ）were negatively correlated with TBIL. α - HBD was positively correlatedwith TBIL r=0.461 P=0.002 ）.ConclusionThere are CK，TBIL and α -HBDchangesin childrenwith HDN，suggesting that thechildren may have cardiac and nervous system function impairment，but there is no obvious linear correlation with HDN.

【Key words】 Creatine kinase；Total bilirubin;A-hydroxybutyrate dehydrogenase；Hemolytic diseasDOI：10.19522/j.cnki.1671-5098.2025.01.012

新生儿溶血病（HDN）是引发高胆红素血症的核心因素之一，人类超过30种血型差异均可能触发HDN[1]。（剩余5613字）