原发性中枢神经系统淋巴瘤与胶质母细胞瘤的多模态诊断：从分子标志物到影像组学

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【中图分类号】R739.41 【文献标志码】A 【文章编号】 1672-7770（2025）06-0714-07

Abstract：Primary central nervous system lymphoma（PCNSL）and glioblastoma（GBM）are central nervous systemmalignant tumors characterizedby high morbidityand mortality.The two diseasesexhibitrelativelysimilar manifestationsonclinicalandconventionalimaging.However，theydifersignificantlyintermsof treatmentresponse and prognosis.This makes the diferentiation between thetwoacritical issue urgentlyrequiring resolution in clinical diagnosis and treatment.In recent years，the rapid advancementof molecular biology and medical imaging technology has opened up newavenues for the non-invasive diffrential diagnosis of PCNSLand GBM.Among these approaches， the analysisof bloodand cerebrospinal fluid biomarkers，maging techniques suchasmagnetic resonance imaging and positronemision tomography，andcomprehensiveanalysis models integrating multi-omics withartificial intellgence have demonstrated tremendous application potential.This article systematicallyreviews the latest research progress in theaforementioned fieldsregarding the diferential diagnosisof PCNSL and GBM，analyzes theadvantagesand limitations of various methods，and prospects their clinical application prospects.Itis expected to provide guidance for clinical practice，improve diagnostic accuracy，and enhance patient prognosis.

Key words：primary central nervous system lymphoma；glioblastoma；biomarker； imaging genomic

胶质母细胞瘤（glioblastoma，GBM）是最常见的恶性原发性脑肿瘤，在中国的发病率为 5/10 万 ～8/10 万，居所有恶性原发性脑肿瘤首位[1]。（剩余20149字）