急性缺血性卒中机械取栓治疗再通后早期神经功能恶化的相关研究进展

【中图分类号】 R743 【文献标志码】 A 【文章编号】 1672-7770（2025）06-0709-05

Abstract：Acute ischemic stroke（AIS），characterized by high morbidity，disability，and mortality rates， remainsacritical cerebrovasculardisease，withan increasing incidence globallinrecent years，especiall inlarge vessel occlusion cases.Mechanical thrombectomy（MT）has emergedas the first-line treatment forAIS.Early neurological deterioration（END），a common post-MT complication，significantly contributes to poor prognosis by elevatingrisksdisabilityandmortality.EarlypredictionandinterventionforENDarepivotalinoptimizingAIS management.This review systematicallinvestigates the mechanismsunderlying END，integrating novel clinical and biological factors topropose predictive modelsand interventional strategies. findingsaim tooptimize therapeutic outcomes and quality life in patientswith AIS.

Keywords：acute ischemic stroke；mechanical thrombectomy；earlyneurological deterioration；reperfusion injury；risk factor

脑卒中是一种高病残率、高病死率的脑血管疾病，其中急性缺血性卒中（acuteischemicstroke，AIS）约占所有卒中病例的 69.6%[1] 。（剩余16547字）