帕金森患者脑萎缩对于丘脑底核脑深部电刺激术中气颅形成以及术后电极位置偏移的影响

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【中图分类号】 R651 【文献标志码】 A 【文章编号】1672-7770（2025）06-0637-06

Abstract： Objective To investigate the influence of brain atrophy on pneumocephalus during subthalamic nucleus deep brain stimulation（STN-DBS）and postoperative lead displacement in Parkinson's disease（PD）. MethodsA retrospective analysis was conducted on 88 Parkinson‘s patients with bilateral STN-DBS admitted to Beijing Temple of Heaven Hospital affiliated with Capital Medical University from October 2018 to June 2O21. The preoperative and one month postoperative clinical evaluation data of all patients were collected.The volumes of various brain regions were assessed by preoperative magnetic resonance imaging（MRI）.The electrode location wasreconstructed based on preoperative MRI，immediate postoperative and longer follow-up computed tomography（CT）. Unilateral pneumocephalus volume percent（uPVP） was also evaluated by using immediate postoperative CT. ResultsPreoperatively，PD patients with more severe brain atrophy exhibited poorer preoperative levodopa response（ P=0.007 ）.Intraoperatively，a significant negative correlation was observed between cerebral cortical volume and uPVP（ P=0 .039）. Postoperatively，a trend toward a negative correlation was observed between cerebral cortical volume and the distance of electrode displacement（ P=0.069 ）. ConclusionsBrain atrophy represents an important factor affecting both the pneumocephalus formation during STN-DBS and postoperative electrode displacement.

Key words： brain atrophy；deep brain stimulation；pneumocephalus； lead displacement

脑深部电刺激（deepbrainstimulation，DBS）是治疗帕金森（Parkinson'sdisease，PD）肌张力障碍等运动障碍性疾病的一种安全有效的治疗方法[1-2]，其中丘脑底核（subthalamicnucleus，STN）是治疗PD最常使用的靶点之一[3-4]。（剩余11922字）