宏基因组高通量测序辅助诊断日本斑点热一例

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中图分类号：R513.3 文献标识码：B 文章编号：1000-503X（2025）01-0146-04

DOI：10.3881/j. issn.1000-503X.15997

Metagenomic Next- Generation Sequencing- Assisted Diagnosis of Japanese Spotted Fever ： Report of One Case

RUAN Yongchun1，ZHOU Yiqing'，ZHANG Haiwang'，ZHOU Jie 1 ，DUAN Jinnan1ZHANG Xiaojing²，LI Minghui'

1 Department of Infectious Diseases，Shaoxing People’s Hospital，Shaoxing，Zhejiang 312Oo，China （20 2 WilingMed Technology（Beijing）Company Limited，Beijing 10023，China

Correspondingauthor：LI Minghui Tel：0575-88559192，E-mail：lmhhx@163.com

ABSTRACT： Japanese spotted fever（JSF） is an infectious disease caused by Rickettsia japonica， with nonspecific clinical symptoms and a high risk of misdiagnosis.We reported acase of JSF，in which Ricketsia japonica was detected in blood cels by metagenomic next- generation sequencing.The patient recovered after treatment with doxycycline.This report provides a reference for the clinical diagnosis and treatment of JSF.

Keywords：Ricketsia japonica；Japanese spotted fever；diagnosis；metagenomicnext-generationsequencing

ActaAcadMedSin，2025，47（1）：146-149

日本斑点热（Japanesespottedfever，JSF）是经蜱虫叮咬传播的一种自然疫源性疾病，于1984年首次在日本发现并报道，后其病原体被建议命名为日本立克次体[1-2]，常见于山区居民和农民，以散发为主，但也有社区聚集的案例报道[3]。（剩余8205字）