代谢相关疾病与草酸钙结石形成机制的研究进展

中图分类号：R692.4文献标识码：A 文章编号：1000-503X（2025）01-0124-07

DOI：10.3881/j. issn. 1000-503X.16038

Research Progress in Metabolism-Related Diseases and Formation Mechanism of Calcium Oxalate Stones

CEN Weihu1， SHEN Jun1.2， XIA Shashal， WANG Qiang1

（204号 1 Department of Urology，The Affiliated Hospital of Guizhou Medical University，Guiyang 55ooo0，China （20 2 Departmentof Urology，Guizhou Hospital，TheFirstAffliated Hospitalof SunYat-sen University，Guiyang 550o，China

Corresponding author：SHENJunTel：13628568909，E-mail：shenjun@gmc.edu.cn

ABSTRACT： Kidney stones are a urinary system disease with a high incidence， among which calcium oxalate stones are the most common.Metabolic disorders such as hypertension，diabetes，obesity，hyperlipidemia，and hyperuricemia can cause changes in oxalate，uricacid，and pH and calcium ion concentrations in the urine through multiple pathways including inducing oxidative stress and inflammatory responses by generating reactive oxygen species，ultimately affcting the formation of calcium oxalate stones.This article reviews the possible pathways and mechanisms by which metabolic diseases influence the formation of calcium oxalate stones， providing new ideas for the clinical prevention and treatment of calcium oxalate stones.

Key words：calcium oxalate stone；metabolism-related diseases；mechanism；reactive oxygen species

ActaAcadMedSin，2025，47（1）：124-130

肾结石在全球范围内的患病率和发病率呈上升趋势[1]，5年内的复发率约为 50% ，其中草酸钙结石为最常见的类型。（剩余15433字）