阑尾影响肠-脑轴相关性疾病发生发展的研究进展

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中图分类号：R741.02 文献标识码：A 文章编号：1000-503X（2025）01-0095-07

DOI：10.3881/j. issn.1000-503X.16046

Research Progress in Effects of Vermiform Appendix on the Occurrence and Development of Diseases Related to Gut-Brain Axis

MO Shuting¹，TIAN Zhe¹，LEI Xin1，HAN Chao²，CHEN Yuhua'

1 Graduate School，Bengbu Medical University，Bengbu，Anhui 23303O，China （204号 2 Departmentof Neurology，TheFirst Afiliated Hospitalof Universityof Sienceand Technologyof China，Hefei230o01，China orresponding author：CHEN Yuhua Tel：O551-62284085，E-mail：yh1215@mail.ustc.edu.c

ABSTRACT： The gut-brain axis is a bidirectional communication pathway connecting the central nervous systemand gastrointestinal tract，playing a key role in the occurrence and development of diseases related to this axis.The vermiform appendix，as a part of the gut that is connected to the cecum，has a unique anatomical location，a rich microbiome，and abundant immune cels.Appendicitis and appendectomy have been found to be asociated with the development of diseases related to the gut-brain axis.This review first introduces the anatomy and functions of the vermiform appendix and then expounds the assciations of appendicitis and appendectomy with diseases related to the gut-brain axis.Furthermore，this review summarizes and prospects the mechanisms of the vermiform appendix in affecting the occurrence and development of diseases related to the gut-brain axis.

Keywords：vermiformappendix；microbiota-gut-brainaxis；inflammatoryboweldisease；Parkinson’sdisease；multiplesclerosis；Alzheimer’s disease

ActaAcadMedSin，2025，47（1）：95-101

肠-脑轴是连接中枢神经系统和胃肠道的双向通信通路。（剩余18794字）