脑白质高信号与主观认知下降相关性的研究进展

中图分类号：R749.1 文献标识码：A 文章编号：1000-503X（2025）01-0110-08

DOI：10.3881/j.issn.1000-503X.15966

Advances in the Correlation Between White Matter Hyperintensity and Subjective Cognitive Decline

ZHANG Jingshi，LIU Guoyun，SHI Anqi，YANG Zeqiu，Mamuke ⋅ Yerebake，WANG Jun，YAN Chaoqun

DepartmentofAcupunctureandMoxibustion，Dongzhimen Hospital，Beijing UniversityofChinese Medicine，BeijingOO7o，China

Corresponding author：YAN Chaoqun Tel：O10-84013147，E-mail：yanchaoqun857@126.com

ABSTRACT： As the population is aging rapidly，the incidence of Alzheimer's disease （AD） is increasing year byyear. The World Health Organization stresss that early prevention plays a keyrole in reducing the incidenceof AD.Subjective cognitive decline （SCD）is an early window of AD development，and timely intervention can efectivelyslow downthe progression of the disease or prevent it from developing into dementia，thus reducing the burden on the society.White matter hyperintensity（WMH） can effectivelyreflect white matter changes and provide strong evidence to identify SCD.In this paper，we review the recent research progress in WMH and SCD，reveal the problems in the current research on WMH，explain the correlation between WMH and SCD in terms of physiopathology and cognitive function，and put forward several suggestions for the future research.

Key words：subjective cognitive decline；white matter hyperintensity；Alzheimer’s disease

ActaAcadMedSin，2025，47（1）：110-117

阿尔茨海默病（Alzheimer’sdisease，AD）是一种进行性大脑疾病，它损害记忆、思维和决策能力，具有高患病率、高致残率和高致死率的“三高”特点[1-2]，造成严重的社会负担。（剩余23786字）