肥胖相关肾疾病的研究进展

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中图分类号：R589.9 文献标识码：A 文章编号：1000-503X（2025）01-0077-09

DOI： 10.3881/j. issn. 1000-503X.16098

Research Progress on Obesity-Associated Kidney Diseases

YANG Ruifeng'，WU Wen2³， ZHANG Peng4

1 Department of Nephrology， 2 Department of General Surgery，Department of Bariatric and Metabolic Surgery，

TheSixth People’s Hospital，Shanghai Jiaotong University Schoolof Medicine，Shanghai 2O1306，China 4Department of Bariatric and Metabolic Surgery，Beijing Friendship Hospital， CapitalMedicalUniversity，Beijing1Ooo5O，China

Corresponding author：WUWen Tel：18116125761，E-mail：wen_wu_struggle@163.com

ABSTRACT：The pathogenesis of obesity-associated kidney disease （OAKD） involves many aspects，including the overactivation of the renin-angiotensin-aldosterone system， insulin resistance，chronic inflammation， disorder of lipid metabolismand imbalance of gut microecology.Treatment strategies for OAKD focuson lifestyle adjustments，pharmacotherapy，bariatric surgery，and fecal microbiota transplantation.Adeeper understanding of the hazards of OAKDandits pathogenesis will contribute to the development of personalized and precise strategies for prevention，diagnosis and treatment of OAKD in the future.

Key words： obesity；obesity-associated kidney disease；pathogenesis；treatment strateg

ActaAcadMedSin，2025，47（1）：77-85

随着全球肥胖率的持续攀升，肥胖已经成为一个严峻的全球性公共卫生问题。（剩余21496字）