铜稳态与疾病研究进展

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中图分类号：R13 文献标识码：A 文章编号：1000-503X（2025）01-0102-08

DOI：10.3881/j.issn.1000-503X.15884

Research Progress in Copper Homeostasis and Diseases

QIU Shuting¹，TAN Xiaohua¹， SHAO Shihan¹，LI Yu1 ， ZHANG Yingying¹， CAO Yuejia' ， DI Chunhong²

1 School of Public Health，Hangzhou Normal University，Hangzhou 311121，China （20 2 Departmentof ClinicalLaboratory，TheAflited HospitalofHangzhouNormalUniversity，Hangzhou31oo15，China

Corresponding author：TANXiaohuaTel：13989864087，E-mail：xiaohuatan@hznu.edu.cn

ABSTRACT：Asan indispensable trace element in the human body，copper plays an important role in various physiological and biochemical reactions.The dyshomeostasis of copper leads to the disorder of copper metabolism and the ocurrence of related diseases.Cuproptosis，a newly proposed regulatory cell death mode，is diffrent from the known apoptosis， pyroptosis，necroptosis，and ferrptosis.Recent studies have found that the dyshomeostasis of copper has been observed in avariety of cancers.Therefore，targeting copper for disease treatment maybecome a new strategy and anew idea.This article systematically summarizes the fundamental properties of copper，copper dyshomeostasis-related diseases （Menkes syndrome，Wilson’s disease，and cancer）and their treatment，and reviews the research progress in cuproptosis.

Key words：copper homeostasis；copper metabolism；cuproptosis；cancei

ActaAcadMedSin，2025，47（1）：102-109

铜作为多个信号传导通路的关键调节因子以及多种酶的辅助因子，在线粒体呼吸、细胞增殖、抗氧化等各类生理过程中发挥着重要作用。（剩余16274字）