香茶菜属萜类化合物免疫调节作用机制及开发应用

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中图分类号R967 文献标志码 A 文章编号 1001-0408（2025）22-2868-05

DOI 10.6039/j.issn.1001-0408.2025.22.20

ABSTRACTPlantsof the Isodon genusareanimportant sourceofterpenoids，withtheirconstituents exhibitingrich structural diversityandremarkablebiologicalactivities（uchasnticancer，antimicrobial，andanti-flammatoryproperties），emostrating significant potentialinthefieldofimmunomodulation.Thisreviewsummarizesrecentadvancesintheimmunomodulatory mechanisms，developmentandapplicationofterpenoidcompoundsfromtheIsodongenus.Ithasbeen foundthatthesecompounds can modulate key inflammatory signaling pathways，such as nuclear factor-kappa B（NF- κB ）and mitogen-activated protein kinases （MAPKs），thereby blocking thecascadeamplificationof inflammatory factors，aleviating chronicinflammatoryresponses，and correctingimmunedysregulation.Aditionaly，theycaninfluencethepolarizationdirectionofmacrophagesanddynamicaly regulatethebalanceamongdiferentfunctional subsetsofTcels，restoringimmunehomeostasis.Theirlinicaltranslationfaces multiplechalenges，including poordruggability，alackof systematicsafetydata，theabsenceof precisepharmacodynamic biomarkers，complexities in clinical trial design，and unclear industrialization pathways.

KEYWORDsIsodongenus；terpenoids；immunomodulation；molecularmechanisms；signaling pathways；structuralmodification

香茶菜属（学名为Isodon，曾归名为Rabdosia）隶属于被子植物唇形科（Lamiaceae），该属的多种植物是我国民间广泛使用的中药，有研究证明，香茶菜属植物具有清热解毒、活血化瘀、抗菌消炎、抗肿瘤和治疗肝炎的功效[-2]。（剩余10799字）