支气管哮喘气道黏液高分泌的发病机制及中药干预研究进展

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中图分类号R965；R285.5 文献标志码A 文章编号 1001-0408（2025）22-2862-06

DOI 10.6039/j.issn.1001-0408.2025.22.19

ABSTRCTBronchialasthma（abbreviatedasasthma）isoneofthecommonchronicairwayinflammatorydiseasesinthe respiratorysystem，whichisdificulttocure.Airwaymucushyperseretion（AMH）isanimportantfactorleadingtoacuteasthma attacks.Traditional Chinesemedicine（TCM）possessstherapeuticadvantagescharacterizedbymultiplepathways，multiple targets，andmultiplelinks，anditsmechanismofactionininterveninginAMHasgradualldrawnatention.TCMcanffectively aleviate thesymptomsof patientsbyinterveninginasthma throughmethodssuchaseliminating phlegmandeliminating fluid retention.Thisreviewfindsthatthepathogenesisofasthma-assciatedAMHiscorelatedwithdecreasedmucociliaryclearance functionand enhanced mucussecretionfunction；singleTCM（suchas Platycodongrandiflorum），effectivecomponentsofTCM （suchas pineliaplysaharides），andcompound prescriptions（mainly heat-clearingandphlegm-resovingprescriptions，etc.）can improveasthma-asociatedAMHbyregulating the PI3K/Aktand JAK/STAT signaling pathways，inhibitingairway inflammatory responses，oxidative stress，and recovering the water-salt ratio of the mucus layer itself.

KEYWORDSbronchial asthma；airwaymucus hypersecretion；traditional Chinesemedicine；pathogenesis；research progre

支气管哮喘（简称“哮喘”是一种以慢性气道炎症为特征的异质性疾病。（剩余9949字）