当归-茯苓药对干预过敏性鼻炎的作用机制预测及验证

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中图分类号R965 文献标志码A 文章编号 1001-0408（2025）22-2778-05

DOI 10.6039/j.issn.1001-0408.2025.22.05

ABSTRACTOBJECTIVETo studythe mechanism of actionof herb pair of Angelica sinensis-Poria cocos in intervening in alergichinitis.METHODsThecoretargetsofherbpairofA.sinensis-P.cocosininterveninginalergichinitiswerepredicted throughnetworkpharmacologyAlergicrhinitismodelofratswasestablishedbyintraperitonealinjectionofaluminumhydroxide andovalbumin mixture，and therats wererandomlydividedinto model group，loratadinegroup（positivecontrolgroup，0.9 mg/kg⋅ ，and low-，medium-，high-dose groups of herb pair ofA.sinensis-P.cocos（3，6 and 12g/kg ），with 10 rats in each group. Another1Ohealthyratswereusedasthenormalgroup.Eachgroupofratswasintragastricalladministeredthecorrespondingliquid ornormalsalineonceadayfor3Oconsecutivedays.Afterthelastadministration，thebehavioralscoresofeach groupofrats were calculated，thelevelsofimmunoglobulinE（IgE），istamin，interleukin-4（L-4）inserum，andeproteinexpresionlevelsof IL-6，tumor necrosis factor- α （TNF- σ⋅α∝ ），and prostaglandin-endoperoxide synthase 2 （PTGS2）in nasal mucosa tissue were detected. Thepathological morphologychangesofnasalmucosa tisuewereobserved.RESULTSNetworkpharmacologyanalysisrevealed thatIL-6，TNFandPGS2mightplayakeyroleintheinterventionofalergicrhinitisbyerbpairofA.sinensis-Pcocosandte IL-17 and TNF signaling pathways might be the typical inflammatory signaling pathways intervened by herb pair of A sinensis-P. cocosinalergicrhinitis.Theresultsofanimalexperimentsshowedthatcomparedwiththemodelgroup，thebehavioralcore，the levelsof IgE，histamine and IL-4，and theprotein expressionsof IL-6，TNF- ∝ and PTGS2 in each administration group were decreased significantly（ （P<0.05 ），and there was a dose-dependent relationship with the herb pair ofA.sinensis-P.cocos（ P<0.05）.CONCLUSIONSThe herbpair ofA.sinensis-P.cocos can effectively alleviate the symptoms of rats with allergic rhinitis，the mechanism of which may be related to the inhibition of the expressions ofIL-6，TNF- α⋅∝ and PTGS2.

KEYWORDS Angelicasinensis; Poria cocos; allergic rhinitis；network pharmacology；mechanism of action

过敏性鼻炎是一种由免疫球蛋白E（immunoglobu-linE，IgE）介导的鼻黏膜炎症反应，常见症状包括打喷嚏、鼻塞、鼻痒、流鼻涕等。（剩余9598字）