开心颗粒的水提工艺优化

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中图分类号R943 文献标志码A 文章编号 1001-0408（2025）22-2790-06

DOI 10.6039/j.issn.1001-0408.2025.22.07

ABSTRACTOBJECTIVE To optimize the water extraction technology for Kaixin granules.METHODS UPLC-MS/MS method Wasestablished for the simultaneousdetermination of ginsenoside Rg1 ，ginsenoside Re， ginsenoside Rb1 ，tenuifolin， polygalaxanthone II and 3， 6′ -disinapoyl-sucrose.An orthogonal test was designed with extraction times，extraction duration，and thevolumeofaddedwaterasfactors.Usingthecontentsoftheaforementionedsixindicatorcomponentsandtheextractyieldas evaluationindexes，analytichierarchyproces-entropyweight method wasemployed todetermine thecombinedweightsofeach indicator.Subsequently，processoptimizationandvalidation wereconductedbyintegratinggreyrelationalanalysis（GRA）andback propagation（BP）neural network.RESULTSThe water extractiontechnologyoptimized bytheorthogonal testandGRA was10- fold waterforthefirstdecoctionand8-fold waterforthesubsequenttwo，extracting3times，extractingfor1heachtime；the average comprehensive score of the validation experiment was 91.10 （RSD=0.31%，n=3） . The water extraction technology optimizedby BP neural network was extracting 3 times with lO-fold water added each time，extracting for 1.5h each time；the average comprehensive score of the validation experiment was 95.89 （RS D=0.73% ， n=3 ）.Considering practical production requirements，theoptimal waterextractiontechnologywasextractionperformed threetimes，with10-foldwaterforthefirst decoctionand8-fold waterforthesubsequenttwo extractions，withan extraction timeof1heach.CONCLUSIONsTheoptimized water extraction technology forKaixin granules is stable and feasible.

KEYWORDSKaixin granules；water extraction technology；analytichierarchy process；entropy weight method;greyrelational analysis；orthogonal test；BP neural network

开心颗粒是由经典名方开心散经水提制备而成的颗粒剂，其处方源于《备急千金要方》，由人参、远志、石菖蒲、茯苓组成，收录于《古代经典名方目录（第一批）》，具有益气养心、安神定志的功效。（剩余9122字）