肾素－血管紧张素－醛固酮系统对维持性血透患者 骨转换的影响

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中图分类号：R692.5 文献标识码：A文章编号：1006-1959(2025)18-0074-04

DOI:10.3969/j.issn.1006-1959.2025.18.016

Effect ofRenin-angiotensin-aldosterone System on Bone Turnover inMaintenanceHemodialysisPatients

CHEN Dan,JIANG Xiaoxiang,ZHOULijia,HU Yueyi

(DepartmentofNephrology,CixiHospitalAfiliatedtoWenzhouMedicalUniversityCixi3153Oo,Zhejiang,China)

Abstract:ObectieTseethtofgotesialdosterosteRAAoeoerinainteacemoalis MethodsAtotalof72patientswithmaintenancehemodialysishoeretreatedinCixiPeople'sHospitalfromNovemberOtoMayee selected.According to thelevel of angiotensin II,the patients were divided into normal angiotensin I group (angiotensin ,41 patients) and elevated angiotensin II group (angiotensin 90 pg/ml,31 patients).Pearson correlation analysis and multiple linear regression analysis were usedtoexploretheinfluencingfactorsofboneturnoverinmaintenancehemodialysispatients.ResultsThelevelsofparathyroidhoone β -CTXand ALP in the elevated angiotensin group were higher than those inthenormal angiotensinII group,and thediferences were statisticallsignificant (P

KeyWords:Maintenance hemodialysis;Renin-angiotensin-aldosterone system; Bone turnover

慢性肾脏病-矿物质和骨代谢紊乱（chronickidney disease-mineral and bone metabolism disor-der,CKD-MBD)是慢性肾脏病(CKD)患者常见的并发症，在慢性肾功能衰竭维持性血透患者中更为常见，国内报道维持性血透患者CKD-MBD患病率在 90% 以上，已经成为影响患者生存质量和生命安全的主要因素之一，骨转换失衡为其常见的病理生理机制。（剩余10345字）