儿童视神经脊髓炎谱系病患者IL-6与体液免疫功能的相关性研究

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中图分类号： R744.5+2 文献标识码：A文章编号：1006-1959（2025）18-0062-04

DOI：10.3969/j.issn.1006-1959.2025.18.013

Study on the Correlation Between Interleukin 6and Humoral Immune Function in Children withNeuromyelitis Optica Spectrum Disorder

DENGDongyangl，HUANGXingfengl，ZHAOYulong1，CHENXiaoxiao1，Yiliyar·Ainivarl，ZHANGMei （1.Departmentof ClinicalMedicine，Xinjiang Medical University，Urumqi83oo54，Xinjiang，China;

ZDepaUuylOlUI Abstract：OetieTetectthveofiteleundmuglobliiatitswidiatriceuroeitisticaspede （NMOSD）ndoesarirolie treatednestfedalofgicalUesieseoodio neurologicaldisodersereseletedasthontrolgoupSSS6.Osoftareasusedfoatisticalaalysiselevelsofinterleui6ad immuoglobliesdee ofintekinetioosttdesatisllte ofIgGIgdiseioooosiolouasaatiolo differences were not statistically significant P>0.05） .After treatment，the level of IL-6in the observation group was lower than that before treatment， andthdieaistllntiletfeiolsfod in the observation group（ P> 0.05）.TherewasamoderatenegativecorrelationbetweenIL-6andIgGintheobservationgroup，andthedifferencewas statistically significant（ P<0.05） .Conclusion IL-6playsacertainrolein the pathogenesis of neuromyelitisoptica spectrum diseases，and hasa certain correlation with immunoglobulin （IgG） ：

Keywords：Neuromyelitisoptica spectrumdisease; Interleukin6;Immunoglobulin

视神经脊髓炎谱系疾病（neuromyelitis opticaspectrumdisease，NMOSD）是一种主要影响视神经和脊髓的中枢神经系统自身免疫性疾病，由体液免疫异常导致脱髓鞘病变。（剩余7672字）