宏基因二代测序技术在社区获得性肺炎中的应用价值

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文献标识码：A

中图分类号：R563.1

文章编号：1006-1959（2025）18-0047-05

DOI：10.3969/j.issn.1006-1959.2025.18.010

Application Value of Metagenomic Next Generation Sequencing in Community-acquired Pneumoni

QINShujuan1，PENGShuihua²，FENGJiemei¹，WUWenbin²，SHAOYouhe1 （DepartmentsofPulmonaryandCriticalCare Medicinel，DepartmentsofPharmacy，Guigang People'sHospital&theEighth AffiliatedHospitalofGuangxiMedicalUniversity，Guigang5371Oo，Guangxi，China）

Abstract：ObjectieTomparetdiagosticfcacyofetageomicetneratiosequencingNtecholondtraditioallabato detectionmethdsinthologofommunityacquiredpeuoa（CA）MtosAerspectivesudyaonuctedtolctCAP patientswhounderentbrochosopyforbonchoalvearlavagefuidspecensandmNGSexamiatioinourhospitalfromJanuarytoJuly 2022.Teclicaldatdeiereseetoldadiioallboatoetetioetsinolocalise compared.ResultsAmongthe173CAPpatients，15Ocases werediagnosedaspositivebymNGS，andthepositiveratewas 86.71% ;59caseswere diagnosed aspositiveby traditional etiological examination，and the positive rate was 34.10% ，thepositive rate of pathogenic detection ofmNGS was highethntatofdioaletioesO）sieitefctealungaleoal bacteria and Nocardia infection was higher than that of traditional methods P<0.05） .Bacterial infections were mainlydue to Gram-negative bacteria， whiletheosogaletoedsluauseofitso 7casesfNocardatatereottetedbytraditoaldeioetodsonlusionGSissuperortoraditioaldtectioetosite etiological diagnosisofCAP，which isof great significanceforthediagnosisandtreatmentofCAPpatients.

Keywords：Commnityacqiedpemoa;Traditoaletectioethos;Metageoicextgeneratioqucing;Eilogicago

社区获得性肺炎（community-acquired pneumo-nia，CAP）病原学构成复杂，特别是对于免疫功能低下的患者，几乎所有细菌、非典型病原体、病毒或真菌都可能被认为是造成CAP的潜在病原体。（剩余8494字）