腐殖质调控农田土壤细菌耐药传播扩散的作用机制研究进展

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中图分类号：S154.3；X172；X53 文献标志码：A 文章编号：2095-6819（2025）05-1140-08 doi：10.13254/j.jare.2024.0876

Role of humus inregulating the proliferation of bacterial antibiotic resistance inagricultural soils ：areview YANGQifan，LIHouyu，ZHANGDandan，XUYan*

（Agro-EnvironmentalProtectionInstitute，MinistryofAgricultureandRuralAffairs，Tianjin3Oo191，China）

Abstract：Duetotewidespreaduseofatibioticsinlivestockandpoultryfarming，theprobleofbacterialresistanceinteagicural environmenthasbenexacerbatedInparticular，themisuseofrganicfertilizerresourcefulnesshasaggravatedthecontaminationof antibioticresistancegenes（ARGs）infamlandsilsBeyondtedirectintroductionofabundantARGscardbyrganicfertliinto thefarmlandenviroent，farlandmusisalsoegardedasacriticalfactorifluencingtecolonzatioandproliferatiooflAs. However，asystematicunderstandingoftepromotingorinbitingeectsndmchanismsofhumusonARGsdisseminationinfaland systemsiscurrntlylacking.Herein，wereviewedthepositiveandnegativeregulatoryrolesofhumusinARGsdissminationwithin farmlandystesdcoltediueingcrssuchsticcalpropetiofsoildsdompofil microbiome.WefurtherclarifedthepathwaysandkeymechanismsbywhichhumusregulatesARGscolonizationanddifusionthrough adsorption，communitysaping，anddiatingelectronrasfer.Moreover，wproposeonstructingelectrohemicaldeviestodeply investigatethemicrobialcommunityfectsofhumusinterventionoizosphereresistancechanges，todfinethefedbackmediatedby plant-microbecoegulation，andtherebytodevelopcriticaltchologiesforefectivelycurbingthespreadofbacterialresistancein farmland.

Keywords：humus;agricultural soil; antibiotics resistance gene; regulation; proliferation

抗生素滥用导致细菌耐药性问题日趋严峻，已成为生态环境和人类健康面临的重大挑战之一。（剩余20657字）