一例猫鼻神经内分泌恶性肿瘤的病理和免疫组化分析
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中图分类号：S857.4 文献标志码：A 文章编号：0366-6964（2025）06-2948-09
Pathological and Immunohistochemical Analysisof A Case of Feline Nasal MalignantNeuroendocrineNeoplasm
ZHENG Yilei 1，2 ， SHEN Fengting1，²，XIN Liang1，YUAN Xiwang1，LIN Lin 3 ， CAO Di 3 ，WU Jiusheng1，²，SHI Fushan1²，WANG Huanan1.，2*
（1.Veterinary Teaching Hospital， Center for Veterinary Sciences， Zhejiang University， Hangzhou 31003O， China ; 2. Department of Veterinary Medicine， College of Animal Sciences， Zhejiang University，Hangzhou 310o30，China ; 3.MetaHealth Veterinary Diagnostic Laboratory，Hangzhou 3l0059，China）
Abstract：The purpose of this article is to report the pathologic and immunohistochemical features of a case of feline nasal malignant neuroendocrine neoplasm. A 4-year-old male British shorthair cat was referred to our hospital after being treated for pneumonia for one month. A nasal mass was found on examination，and a surgical biopsy was performed to remove the nasal mass for histopathological and immunohistochemical examination. A biopsy of the nasal mass was performed for histopathological and immunohistochemical examination. Histopathological findings indicate that the tumor cells exhibit significant variability in size and shape，with marked atypia. The nuclei are predominantly vesicular，and the tumor has invaded surrounding tissues. Immunohistochemical results show positive staining for neuron-specific enolase （NSE）， synaptophysin （Syn）， vasoactive intestinal peptide（VIP），and CD99 （cluster of differentiation 99，CD99）. Based on laboratory tests， histopathology and immunohistochemistry，the final diagnosis was nasal malignant neuroendocrine neoplasm and more inclined to poorly diferentiated neuroendocrine carcinoma （NEC）. This case hoping to provide a reference for diagnosing this tumor and differentiating it from other nasal cavity tumors.
Keywords： cat；neuroendocrine neoplasm；histopathology；immunohistochemistry ∗ Corresponding author： WANG Huanan，E-mail： hnwang@ zju. edu. cn
神经内分泌细胞在胚胎学上来源于肠道，广泛分布于各种组织中。（剩余14466字）