猪流行性腹泻病毒的天然免疫逃避机制及其防控研究进展

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中图分类号：S852.65 文献标志码：A 文章编号：0366-6964（2025）06-2590-10

Innate Immune Evasion Mechanisms of Porcine Epidemic Diarrhea Virus and Advances in Prevention and Control Strategies

WU Chao1，MING Wenhan1，LU Shuwan1，YANG Caimei1，LIU Jinsong² MA Xiang1，ZHANG Ruiqiang1

（1. Zhejiang Provincial Engineering Laboratory for Animal Health Inspection & Internet Technology ， Key Laboratory of Applied Technology on Green-Eco-Healthy Animal Husbandry of Zhejiang Province， College of Animal Science and Technology， College of Veterinary Medicine， Zhejiang

Agricultural and Forestry University，Lin'an 31130o， China ; 2.Zhejiang Vegamax Biotechnology Co.，Ltd.，Vegamax Green Animal Health Products Key Agricultural Enterprise Research Institute，Anji 3l3300，China）

Abstract： Porcine epidemic diarrhea （PED） is an acute，highly contagious intestinal infectious disease caused by porcine epidemic diarrhea virus （PEDV），characterized primarily by vomiting， dehydration，and diarrhea. In recent years，the emergence of variant PEDV strains has led to significant economic losses in the pig farming industry in many countries. Therefore，investigating the pathogenic mechanisms of PEDV and identifying effective prevention and control measures are essential to ensuring the health and productivity of pig farming. This review summarizes the mechanisms by which PEDV evades host immune responses，including the inhibition of interferon production and the regulation of apoptosis， autophagy， pyroptosis， and inflammatory responses.

Additionally，it discusses the progress in vaccine development and nutritional interventions aimed at controlling PEDV，providing a theoretical foundation for the effective control of PED.

Keywords： porcine epidemic diarrhea virus; escape mechanism； prevention and control measures ∗ Corresponding author： ZHANG Ruiqiang，E-mail： zrql034 @ 163.com

猪流行性腹泻病毒（porcineepidemicdiarrheavirus，PEDV是一种包膜病毒，其引发的猪流行性腹泻（porcineepidemicdiarrhea，PED）是一种高度传染性的病毒性肠炎[1]。（剩余24262字）