母羊下丘脑-垂体-性腺轴调控其子宫复旧机制研究进展

中图分类号：S826.3 文献标志码：A 文章编号：0366-6964（2025）06-2525-12

Research Progress on the Regulation of Uterine Involution in Ewesby the Hypothalamic-Pituitary-Gonadal Axis

MA Qingling1'²，WANG Zhiyou²，HOU Shengzhen1 ，YANG Chao1* （1.State Key Laboratory of Sanjiangyuan Ecology and Plateau Agriculture and Animal Husbandry， Qinghai University， Xining 81oo16， China; 2.College of Agriculture and Animal Husbandry，Qinghai University，Xining 81oo16，China）

Abstract： Uterine involution represents a crucial component of the reproductive process in animals，with the extent of involution being a key determinant of whether a female animal can achieve subsequent pregnancy. The completion of uterine involution in female animals postpartum is influenced by a variety of factors， including nutrition，postpartum care，and the season of parturition. In ruminants， this process is primarily regulated by the hypothalamic-pituitary-gonadal axis （HPGA）. However，current research on the mechanisms underlying uterine involution in ewes remains fragmented，and the specific regulatory pathways of the HPGA in this context are not yet fully elucidated. This review aims to comprehensively examine the mechanisms of uterine involution in ewes，the factors influencing this process，and the role of the HPGA. It is intended to provide a foundational reference for a deeper understanding of the significance of the HPGA in uterine involution in ewes and to offer a theoretical basis for future research into the regulatory mechanisms of the HPGA in this area.

Keywords： ewe； uterine involution; hypothalamic-pituitary-gonadal axis； regulatory mechanism ∗ Corresponding author：YANG Chao，E-mail： yangchao@qhu. edu. cn

繁殖对于所有动物的生存和进化至关重要，营养、遗传、产后管理、应激控制等多种因素直接或间接影响动物的繁殖性能[1]。（剩余30226字）