体外对猪流行性腹泻病毒复制具有抑制效应的物质

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中图分类号：S852.659.6 文献标志码：A 文章编号：0366-6964（2025）06-2577-13

Substances with Inhibitory Effects on Porcine Epidemic Diarrhea Virus Replication in vitro

WANG Yunke1，2.3，4， WANG Na1，2，3，4∗ ，YUE Ke1，2，3，4 ， HE Kunmiao 1，2，3，4 ， ZHANG Xing1，2，3，4LIU Yao1，2.3，4 ， ZHANG Gaiping1，2.3 *

（1.College of Veterinary Medicine， Henan Agricultural University， Zhengzhou 45O046， China; 2. International Joint Research Center of National Animal lmmunology， Zhengzhou 45O046， China; 3.Longhu Laboratory， Zhengzhou 450046，China ; 4. Zhengzhou Key Laboratory of Nutrition and Health Food， Zhengzhou 450002， China）

Abstract： Porcine epidemic diarrhea virus （PEDV） is a virus that causes acute diarrhea，vomiting，dehydration，and other symptoms in piglets.Due to its high incidence rate and high mortality，it has caused substantial economic losses to the global pig industry. Although vacination is currently the most economical and effective measure for preventing porcine epidemic diarrhea （PED），the frequent emergence of PEDV variants has resulted in poor immune protection from existing vaccines，making the development of effective antiviral drugs particularly urgent. In recent years，researchers have been dedicated to screening and evaluating substances with potential anti-PEDV activity， which mainly exert their effects by targeting the invasion，replication，or assembly processes of the virus，or by enhancing the host’s immune response. This article provides an overview of the anti-PEDV effects and mechanisms of chemical drugs， natural products，and other biological agents，in order to provide new directions and ideas for the screening and research of anti-PEDV drugs.

Keywords： porcine epidemic diarrhea virus； chemical drugs； natural products； biological agents∗ Corresponding authors： WANG Na，E-mail： na-wang 163.com；ZHANG Gaiping E-mail：zhanggaip@126.com

猪流行性腹泻（porcineepidemicdiarrhea，PED）是由猪流行性腹泻病毒（porcineepidemic di-arrheavirus，PEDV）引起的一种急性肠道疾病。（剩余24459字）